Transmission- and side-detection configurations in ultrasound-modulated optical tomography of thick biological tissues.
نویسندگان
چکیده
Ultrasound-modulated optical tomography of thick biological tissues was studied based on speckle-contrast detection. Speckle decorrelation was investigated with biological tissue samples of various thicknesses. Images of optically absorbing objects buried in biological tissue samples with thicknesses up to 50 mm were obtained in a transmission-detection configuration. The image contrast was more than 30%, and the spatial resolution was approximately 2 mm. In addition, a side-detection scheme along with two specific configurations were examined, and the advantages were demonstrated. Experimental results implied feasibility of applying the ultrasound-modulation technique to characterize optical properties in inhomogeneous biological tissues.
منابع مشابه
Ultrasound-modulated Optical Tomography for Biomedical Applications
Ultrasound-modulated Optical Tomography for Biomedical Applications. (August 2004) Jun Li, B.Eng., Huazhong University of Science and Technology; M.Eng., Huazhong University of Science and Technology; Ph.D., Huazhong University of Science and Technology Chair of Advisory Committee: Dr. Lihong V. Wang I experimentally studied ultrasound-modulated optical tomography, which holds the promise for b...
متن کاملPhotorefractive detection of tissue optical and mechanical properties by ultrasound modulated optical tomography.
Ultrasound-modulated optical tomography is a developing hybrid imaging modality that combines high optical contrast and good ultrasonic resolution for imaging soft biological tissue. We developed a photorefractive-crystal-based, time-resolved detection scheme with the use of a millisecond long ultrasound burst to image both the optical and the mechanical properties of biological tissues, with i...
متن کاملUltrasound-Mediated Biophotonic Imaging: A Review of Acousto-Optical Tomography and Photo-Acoustic Tomography
This article reviews two types of ultrasound-mediated biophotonic imaging-acousto-optical tomography (AOT, also called ultrasound-modulated optical tomography) and photo-acoustic tomography (PAT, also called opto-acoustic or thermo-acoustic tomography)-both of which are based on non-ionizing optical and ultrasonic waves. The goal of these technologies is to combine the contrast advantage of the...
متن کاملSentinel lymph node detection ex vivo using ultrasound-modulated optical tomography.
We apply ultrasound-modulated optical tomography (UOT) to image ex-vivo methylene-blue-dyed sentinel lymph nodes embedded in 3.2-cm-thick chicken breast tissues. The UOT system is implemented for the first time using ring-shaped light illumination, intense acoustic bursts, and charge-coupled device (CCD) camera-based speckle contrast detection. Since the system is noninvasive, nonionizing, port...
متن کاملTheoretical and experimental studies of ultrasound-modulated optical tomography in biological tissue.
Ultrasound-modulated optical tomography in biological tissue was studied both theoretically and experimentally. An ultrasonic beam was focused into biological tissue samples to modulate the laser light passing through the ultrasonic beam inside the tissue. The ultrasound-modulated laser light reflects the local optical and mechanical properties in the ultrasonic beam and permits tomographic ima...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Applied optics
دوره 42 19 شماره
صفحات -
تاریخ انتشار 2003